The Approach: the Endothelium

The innermost layer of blood vessels is composed primarily of a single layer of endothelial cells called endothelium, which serves as a barrier between the blood stream and the underlying tissues.

Endothelial cells play a crucial role in preserving blood fluidity and preventing thrombotic reactions by secreting various mediator proteins and molecules that modulate coagulation, platelet aggregation, leukocyte adhesion and vascular tone. 

Blood vessel Structure Cell

 

 

 

 

  

 

 

 

Lack of endothelial cells on a surface exposed to the blood stream leads to immediate deposition of plasma proteins, followed by platelet and leukocyte adhesion and finally to fibrin deposition, thus reducing the lumen of the vessel and compromising blood supply.

Vascular implants should minimize endothelial damage of the host blood vessel, and promote endothelialization to reduce the risk of thrombosis.

Vascuzell provides the technologies required to incorporate and preserve the benefits of the endothelium and other vascular cells in any novel implant design.