The Challenge: Vascular Biocompatibility

Among all implants, prosthesis permanently exposed to the blood stream (e.g. vascular grafts, stents, heart valves, etc.) must fulfill the most stringent biocompatibility requirements to guarantee implant acceptance.

The blood stream with its multiple responsive mechanisms to physiological stimuli, presents a highly complex and challenging environment to any biomaterial.

The long term success of synthetic implants has been limited by their failure to capture and respond to the dynamic vascular environment.

Vascular implants exhibiting a limited biocompatibility could induce thrombosis, restenosis, inflammation, and hyperplasia. These complications generally lead to a narrowing  or blockage of the blood vessel, potentially compromising blood supply to vital organs. To reduce the risk of implant rejection, patients require adjuvant pharmacological treatments.

To overcome existing limitations in the future generations of vascular implants, Vascuzell incorporates the advantages of endothelial cells, the optimal antithrombogenic active surface.